This was confirmed by the lead actor of the original game, Norman Reedus.
In an interview, the actor said that he was involved in the creation of a sequel to Death Stranding, but did not specify whether his character would become the main character or someone else would take his place. According to Reedus, production on the game has recently begun.
Death Stranding was released on PS4 in 2019. A PC port followed in 2020, and Death Stranding: Director’s Cut was released for PS5 in 2021 (the Director’s Cut was released on PC in 2022).